Corona vaccination protects in all weight categories

Corona vaccination protects in all weight categories

Obesity is a major risk factor for severe forms of Covid-19 and weakens the immune system. Conversely, vaccination protects in all “weight classes”. This is the result of a study with data from nine million people in Britain. Another scientific study showed that temporarily stopping immunosuppressive drug treatment for rheumatism improves the effect of SARS-CoV-2 vaccines.

In the treatment of immunocompromised rheumatism, a break after vaccination may be advised

In the treatment of immunocompromised rheumatism, a break after vaccination may be advised

“One in five people worldwide are at particular risk of severe course of SARS-CoV-2 infection due to additional health problems. There is consistent evidence that obesity is an independent risk factor important,” wrote Carmen Piernas and her co-authors in Lancet Diabetes and Endocrinology ( Additionally, there appears to be a correlation between obesity and a lower response to vaccination.

Assessed data from over 9 million people

For the scientific study, the experts therefore assessed the data of 9,171,524 people who were registered in England with family doctor practices under the National Health System (NHS). The observation period took place from December 8, 2020, the date of the first vaccinations against Covid-19 in England, and November 17, 2021. The information was analyzed according to several “weight classes”: a BMI (Index of Body Mass) less than 18.5 (underweight), BMI from 18.5 to 24.9 (normal weight), overweight: BMI from 25 to 30 and obese (BMI over 30). The mean age was 52 years, the mean BMI value 26.7. This also means that people in England are overweight on average.

As the experts have documented, all people who had been vaccinated at least twice against Covid-19 had a high protective factor against hospitalizations following Covid-19: this risk was reduced by 49% in underweight people two weeks after vaccination and 66%. percent among normal weight people, among overweight people 68 percent. The effect of vaccination in obese people was just as high as in overweight people. The protection rate against death from Covid-19 was 40% for underweight people, 61% for normal weight people, 70% for overweight people and 74% for obese people. Some of the lower protective factor among underweight people may be due to lower vaccination coverage in this group. There should be more efforts to promote vaccination there, the scientists wrote.

Methotrexate reduces vaccine effectiveness

British scientists recently published an important finding in “Lancet Respiratory Medicine” (DOI: 10.1016/S2213-2600(22)00186-2; June 27). Many people suffer from chronic inflammatory diseases and receive – for example, in the case of rheumatoid arthritis (“rheumatoid arthritis”), psoriasis, etc. – medicines that weaken the immune system. Low doses of the cytostatic methotrexate, which was previously mainly used in oncology, are the most used here. For example, it is one of the most important effective drugs in the treatment of chronic polyarthritis. But on immunosuppressive therapy, people respond less well to vaccinations.

British scientists have now tested a possible outcome to the Covid 19 vaccination. Since last autumn, they have admitted 254 patients with rheumatoid arthritis (about half), psoriasis (34%) and other inflammatory diseases chronicles. All were treated with methotrexate. After the third partial vaccination against Covid-19, methotrexate treatment was then suspended for two weeks in 50% of these people.

Then, from the University of Nottingham, Abhishek Abhishek and his team of authors measured the antibody response in the two groups of subjects. It turned out that patients with a methotrexate pause developed a slightly more than twice as high antibody response to the third partial Covid 19 vaccination as those who continued to be treated with the cytostatic. On the other hand, up to three months after discontinuation of MTX treatment, chronic inflammatory disease resurfaced in just over 70% of subjects. However, these flare-ups were mild and easy to manage. However, such a procedure should always be discussed and discussed with the doctor treating you.

(APA/red, photo: APA/APA/dpa/Moritz Frankenberg)

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